A New Protocol to Synthesize Di(indolyl)pyrazolyl Methanes Using H_2PtCl_6 as a Catalyst in Ionic Liquid:Synthesis of Novel 3-[1H-indol-3-yl(3-phenyl-1H-pyrazol-4-yl)methyl]-1H-indoles

摘要

Biologically important di(indolyl)pyrazolyl methanes and their derivatives were synthesized in excellent yields by the electrophilic substitution of indole with pyrazolyl aldehydes catalyzed by H_2PtCl_6 in ionic liquid.Indole forms an integral part of many natural products of therapeutic importance and possesses potentially reactive sites for a variety of chemical reactions to generate molecular diversity.Bisindolylalkanes and their derivatives are found in bioactive metabolites of terrestrial and marine origin.Several bis(indole)alkaloids,which exhibit biological activity including antibacterial,antiviral,and cytotoxic activities,have been isolated from the marine environment.