Components for tethered bilayer membranes:synthesis of hydrophilically substituted phytanol derivatives

摘要

In order to optimize the perofrmance of the AMBRI~(TM) biosensor,a variety of hydrophilic linkers between the hydrophobic bilayer membraneand the gold surface have been synthesized.The principal components are prepared form phytanyl hemisuccinate,which is linked by repeating ethylene glycol or propylene glycol units to a second succinic acid unit.The syntheses of analoguous substances in which the ester linkes are replaced by amide and by ether links are also described.