Copper(II) Complexes with Reduced Schiff Base:Synthesis,Spectroscopic,Thermal,X-Ray,and Cytotoxic Studies of Novel Copper(II) Complexes with an Arylpyrazole Ligand

摘要

The synthesis of a novel arylpyrazole-derived ligand,l,2-bis[(l,3-diphenylpyrazol-4-yl)methyl]diaminoethane (Ph4Pz2mde),and its complexes prepared with CuCl2 [Cu(Ph4Pz2mde)Cl2(MeOH)] 1,CuBr2 [Cu(Ph4Pz2mde)Br2 (MeOH)] 2,from MeOH,and [Cu(Ph4Pz2mde)Cl2(DMF)] 3,from a mixture of MeOH and DMF,are described.The complexes are characterized by elemental and thermal analysis and FT-IR spectroscopy,while the ~1H and ~(13)C NMR assignments are given for the ligand.The crystal and molecular structure of [Cu(Ph4Pz2mde)Cl2(DMF)] was determined by single-crystal X-ray diffraction.In vitro cytotoxicity of the Ph4Pz2mde ligand and two copper(II) complexes was obtained using sulforhodamine B (SRB) treatment against three human tumour cell lines:HeLa (epitheloid carcinoma of cervix),MCF-7 (breast adenocarcinoma),and MRC-5 (lung fetal fibroblasts).