The Synthesis and Biological Evaluation of Two Analogues of the C-Riboside Showdomycin

摘要

Two novel analogues,2 and 3,of the C-riboside showdomycin (1) have been prepared by exploiting the N-TIPS-substituted pyrrole 7 as a synthetic equivalent for the maleimide C3 anion.The tetraacetate precursor,12,of target 2 as well as target 3 itself were subjected to single-crystal X-ray analyses.Analogues 2 and 3 as well as showdomycin and its anomer (4) have each been evaluated in various assays for their cytotoxic,anti-bacterial,and anti-viral effects.