Cognitive dysfunctions persist after recovery from acute depression and are considered a risk factor for its recurrence. Improving neurocognitive and psychosocial functioning is a main treatment goal for depression. This manuscript reviews currently available treatment options for cognitive dysfunction of depression. Pharmacotherapy has not shown satisfactory effects on cognitive dysfunction. Cognitive behavioral therapy also can be applied to improve cognitive dysfunction in major depressive disorder. Cognitive remediation treatment (CRT) is an attractive treatment option for neurocognitive symptoms in major depressive disorder. CRT has shown beneficial effects on depressive symptoms, psychosocial functioning, and cognitive functioning. Recently, digital therapeutics have emerged as a new treatment modality to enhance and maintain the efficacy of CRT. Well-designed, well-powered randomized controlled trials are needed to investigate the short-and longterm effects of CRT on depressive symptoms and cognitive functioning. Optimal treatment protocol format according to specific subgroups of depression is also needed. [Psychiatr Ann. 2022;52(3):109-113.]
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