Expression analysis of microRNA-155 in type 2 diabetes in Kashmiri population

摘要

Purpose The present study aimed to evaluate the expression of microRNA-155 (miR-155) in type 2 diabetes mellitus (T2DM) and assess its correlation with clinicopathological characteristics of this type. Methods MiR-155 expression was detected in 20 T2DM blood samples and 23 blood samples of healthy controls using fluorescent reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The association between miR-155 expression and clinicopathological features was also analyzed. Result We found higher values of quantitative parameters like blood pressure, blood sugar levels, and weight in cases compared to controls (p 0.05). We evaluated miR-155 expression between males and females; however, we found no gender-specific difference in the expression. Patients exhibiting high miR-155 expression levels were observed to have short duration of T2DM than that of patients with reduced expression of miR-155; however, this difference was not statistically significant (p > 0.05). Conclusion The current results demonstrated that miR-155 may be involved in resistance against T2DM and may be negatively associated with clinical parameters of T2DM patients. The study was limited by its observational study design, so additional studies involving pathophysiology are required to clarify the role of miR-155 in T2DM.