Synthesis and cytotoxicity studies of new 1,2,4-thiadiazole derivatives and their zinc complexes

摘要

A new polyfunctional ligand of the thiadiazole family was synthesized. Cytotoxic properties with respect to leukemic cell lines, radiation stability, predicted permeability through the blood-brain barrier and cardiotoxicity of the new ligand and its precursor were determined. New zinc complexes with N-{2-5-(3-chloro-4-methylphenylamino)-1,2,4-thiadiazol-3-yl -1-methylethyl}-N-(2,2,6,6-tetramethylpiperidin-4-yl)-amine as the ligand have been obtained.