ACP Journal Club. Decolonization of nostrils and skin of nasal carriers of S. aureus at admission prevented hospital-associated infection.

摘要

Does rapid identification of nasal carriers of Staphylococcus aureus and immediate decolonization of the nostrils and skin prevent hospital-associated infection with S. aureus? Methods Design: Randomized placebo-controlled trial. Current Controlled Trials ISRCTN56186788. Allocation: Unclear concealment. Blinding: Blinded (patients, clinicians, data collectors, and laboratory personnel). Follow-up period: 6 weeks after hospital discharge. Setting: Surgical and internal medicine wards in 3 university hospitals and 2 general hospitals in the Netherlands.Patients: 918 adults (mean age 62 y, 63% men, 88% surgical) who were positive on rapid screening (by real-time polymerase chain reaction [PCR]) for nasal carriage of S. aureus at hospital admission and were expected to be in hospital > 4 days. Exclusion criteria included active infection with S. aureus, pregnancy, and use of mupirocin in < 4 weeks.