Successful treatment of generalized pustular psoriasis with the interleukin-1-receptor antagonist Anakinra: lack of correlation with IL1RN mutations.

摘要

Background: Generalized pustular psoriasis (GPP) is a multisys-temic inflammatory disease with disseminated pustular skin involvement that often responds poorly to currently available treatments, including tumor necrosis factor (TNF)-a inhibitors (1). The recent identification of mutations in the IL1RN gene coding for the inter-leukin (IL)-1 receptor antagonist in an autoinflammatory syndrome with pustular skin involvement provides a rationale to investigate the contribution of the IL-1beta pathway to the pathogenesis of GPP (2). Objective: To report the efficacy of the recombinant IL-1 receptor antagonist anakinra and to search for IL1RN gene mutations in 2 patients with GPP.