Annual or biennial FOBT screening reduced colorectal cancer mortality, but not all-cause mortality, at 30 years

摘要

Does colorectal cancer screening using fecal occult blood testing (FOBT) reduce long-term all-cause and disease-specific mortality?Methods Design: Randomized controlled trial (Minnesota Colon Cancer Control Study).Allocation: {Concealed}Blinding: Blinded (adjudicators of colorectal cancer mortality during the first 15 y of the study).Follow-up period: 30 years.Setting: Minnesota and Wisconsin, USA.Participants: 46 551 healthy adults 50 to 80 years of age (mean age 62 y, 52% women).