Review: Antibiotics reduce treatment failure in acute chronic obstructive pulmonary disease exacerbations

摘要

Question Do antibiotics improve outcomes in acute chronic obstructive pulmonary disease (COPD) exacerbations? Review scope Included studies compared > 2 days of daily antibiotics with placebo in patients with acute COPD exacerbations. Studies had to include > 90% of COPD patients who were > 40 years of age; trials of clinically diagnosed COPD had to include > 90% of patients with a history of smoking. Studies of patients with acute bronchitis, pneumonia, asthma, or bronchiectasis were excluded. Outcomes included treatment failure (no symptom resolution or deterioration after treatment, or death due to exacerbation or medication including study antibiotics) at 7 days to 1 month, mortality, and adverse events.