Long noncoding RNAs: role and contribution in pancreatic cancer

摘要

Noncoding RNAs are proclaimed to be expressed in various cancer types and one such type is found to be pancreatic ductal adenocarcinoma (PDAC). The long noncoding RNAs (LncRNAs) affect the migration, invasion, and growth of tumor cells by playing important roles in the process of epigenesis, post-transcription, and transcriptional regulation along with the maintenance of apoptosis and cell cycle. It is quite subtle whether the alterations in IncRNAs would impact PDAC progression and development. Thisreview throws a spotlight on the IncRNAs associated with tumor functions: MALAT-1, HOTAIR, HOXA13, H19, LINC01559, LINC00460, SNHG14, SNHG16, DLX6-AS1, MSC-AS1, ABHD11-AS1, DUXAP8, DANCR, XIST, DLEU2, etc. are upregulated IncRNAs whereas GAS5, HMIincRNA717, MIAT, LINC01111, IncRNA KCNK15-AS1, etc. are downregulated IncRNAs inhibiting the invasion and progression of PDAC. These data provided helps in the assessment of IncRNAs in the development, metastasis, and occurrence of PDAC and also play a vital role in the evolution of biomarkers and therapeutic agents for the treatment of PDAC.