Generic antiretrovirals and the uncertain future of HIV care in the United States

摘要

Generic antiretroviral drugs have contributed to remarkable achievements in the global HIV epidemic. Mortality has decreased by 24% since 2005, new HIV infections have decreased by 20% since 2001, and 8 million persons are receiving treatment (1). In the United States, 10 available generic antiretrovirals have been used infrequently because of greater toxicity and inferior efficacy. However, when generic efavirenz becomes available in 2013, a regimen of generic efavirenz and lamivudine with branded tenofovir will become a credible alternative to branded regimens.