Development of biocompatible and biofilm-resistant silver-poly(methylmethacrylate) nanocomposites for stomatognathic rehabilitation

摘要

Recurrent prosthesis fracture and microbial contamination of the tissue bed or prosthetic materials remain the major clinical challenge for successful intraoral/faciomaxillary rehabilitation. Biocompatible and biofilm-resistant silver nanoparticle (AgNPs) based on poly(methyl methacrylate) was successfully developed by a compression-molding technique. The AgNP-loaded PMMA were characterized using TEM, SEM, FT-IR and XRD analysis. The nanocomposites were found to be biocompatible and biofilm-resistant against Streptococcus mutans and Candida albicans. Mechanical performance of the nanocomposite was statistically analysed and modulus of elasticity was theoretically predicted using four models. The biomaterial developed in this study can be effectively used for stomatognathic rehabilitation.