Electrospun silk fibroin/beta-cyclodextrin citrate nanofibers as a novel biomaterial for application in controlled drug release

摘要

A novel beta-cyclodextrin-grafted silk fibroin (SF) nanofibers was successfully fabricated. The morphology and diameter of the electrospun nanofibers were characterized. FE-SEM images showed that the morphology and diameter of the nanofibers were mainly affected by weight ratio of the blend. FTIR, H-1-NMR, DSC and TGA confirmed the crosslinking reaction between beta-cyclodextrin and SF. The release rate of Ciprofloxacin was measured and observed that the SF-g-CD nanofibrous mat provided slower release of the entrapped drug when compared with SF nanofibrous mat. A mathematical analysis of the drug release data suggested that the Higuchi model was the best fitted model.