Enabling High-Performing Perfusion Cell Culture

摘要

At least one report estimates that by 2025, 35% of biologies will be manufactured using enhanced processes, particularly perfusion-based bioprocessing (l). Results of two innovations that support this need for enhanced processes are examined below.The Thermo Scientific HyPerforma1" DynaDrive Single-Use Bioreactor (SUB), the latest advancement in SUB technology, offers better performance than other bioreactors and scalability up to 5,000 L. Gibco High-Intensity Perfusion CHO Medium is formulated toprovide exceptional performance and ease of use, with capability of sustaining >1 g/L/day continuous productivity, >100 x 106/mL cell density, and 95% viability at one vessel volume per day (WD).