Two Routes for the Synthesis of Phosphorothioates via P-S Coupling Reaction of Dialkyl Phosphites with Thiols or a Mixture of Alkyl Halides and Thiourea in the Presence of CaO

摘要

abstract_textpIn this report, two routes for the synthesis of phosphorothioatesviaa P-S cross coupling reaction of thiols with dialkyl phosphites or a three component reaction of alkyl halides, thiourea and dialkyl phosphite in the presence of CaO has been studied. By presented methods, various phosphorothioates are obtained under transition metal-free condition. The reactions are proceeded with formation of a known intermediate of disulfideviathe oxidation of thiols and followed by nucleophilic substitution of dialkyl phosphite with the disulfide intermediate gave phosphorothioate./p/abstract_text