Hydropersulfides are endogenous antioxidants that inhibit ferroptosis

摘要

Hydropersulfides are implicated in cellular responses to oxidative stress. In two landmark papers, Barayeu et al. and Wu et al. reveal that endogenous hydropersulfides are hydrogen atom donors that scavenge lipid radicals, thereby preventing lipid peroxidation and ferroptosis. Thus, the pathways governing hydropersulfides may represent a new cellular ferroptosis suppression system.