t-BuOK-Mediated Transition-Metal-Free Direct Olefination and Alkylation of Methyl N-Heteroarenes with Primary Alcohols under Control of Temperature

摘要

Transition-metal-free, temperature-controlled chemoselectivities of alkenylazaarenes and alkylazaarenes through t-BuOK/18-crown-6 promoted functionalization reaction of methyl-substituted N-heteroarenes with primary alcohols has been established. Following the methodology, a variety of olefinated and alkylated N-heteroarenes have been efficiently obtained. To understand the mechanism of the reactions, various control and kinetic experiments were carried out.