Halocyclopentadienes:An Emerging Class of Toxic DBPs in Chlor(am)inated Drinking Water

摘要

Although>700 disinfection by-products(DBPs)have been identified to date,most DBPs in drinking water are still unknown.Identifying unknown DBPs is an important step for improving drinking water quality because known DBPs do not fully account for the adverse health effects noted in epidemiologic studies.Using gas chromatography high-resolution mass spectrometry,six chloro-and bromo-halocyclopentadienes(HCPDs)were identified in chlorinated and chloraminated drinking water via non-target analysis; five HCPDs are reported for the first time as new alicyclic DBPs.Formation pathways were also proposed.Simulated disinfection experiments with Suwannee River natural organic matter(NOM)confirm that NOM is a precursor for these new DBPs.Further,HCPDs are more abundant in chlorinated drinking water(real and simulated)when compared to chloraminated drinking water due to the higher reactivity of chlorine.Of these new DBPs,l,2,3,4,5,5-hexachloro-l,3-cyclopentadiene is approximately 100,000x more toxic(in vivo)than regulated trihalomethanes(THMs)and haloacetic acids(HAAs)and 20-2000X more toxic than halobenzoquinones,halophenols,and halogenated pyridinols using the available median lethal dose(LD_(50))and concentration for 50% of maximal effective concentration(EC_(50))of DBPs to aquatic organisms.The predicted bioconcentration factors of these HCPDs range from 384 to 3980,which are 2-3 orders of magnitude higher than those for regulated and priority DBPs(including THMs,HAAs,halobenzoquinones,haloacetonitriles,haloacetamides,halonitromethanes,haloacetaldehydes,iodo-THMs,and iodo-HAAs).Thus,HCPDs are an important emerging class of DBPs that should be studied to better understand their impact on drinking water quality and long-term human health exposure.