Purpose: To evaluate the visual and refractive outcomes of trifocal intraocular lens (IOL) implantation in eyes previously treated with myopic and hyperopic corneal refractive laser surgery. Setting: Clinica Baviera-AIER-Eye group, Spain. Design: Retrospective comparative case series. Methods: The series was divided into 2 groups according to the type of corneal laser refraction (myopic and hyperopic). The main visual and refractive outcome measures included corrected distance visual acuity (CDVA) and uncorrected distance and near visual acuity, safety, efficacy, and predictability. The sec-ondary outcome measures were percentage of enhancement and Nd:YAG capsulotomy and influence of prelaser magnitude of myopia and hyperopia on the outcome of trifocal IOL implantation. Results: The sample comprised 868 eyes (543 patients): myopic, n = 319 eyes (36.7%); and hyperopic, n = 549 eyes (63.2%). Three months postoperatively, visual outcomes were poorer in the hyperopic group than those in the myopic group for mean CDVA (0.06 +/- 0.05 vs 0.04 +/- 0.04, P +3.0 diopters [D]) and poorer precision in the high myopia subgroup (<-5.0 D). Conclusions: Trifocal IOL implantation after photorefractive sur-gery in eyes previously treated with myopic ablation achieved good visual outcomes but less predictability in the high myopia subgroup. However, eyes with a previous hyperopic corneal ablation achieved excellent precision but worse visual and safety outcomes in the high hyperopia subgroup. J Cataract Refract Surg 2021; 47:1265-1272 Copyright (c) 2021 Published by Wolters Kluwer on behalf of ASCRS and ESCRS
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