EFFECT OF SURFACTANT AND METHODS OF DRYING ON METHOTREXATE HYDROCHLORIDE LOADED CHITOSAN BEADS

摘要

? 2023 Indian Drug Manufacturers' Association. All rights reserved.To get chitosan beads, an ionotropic gelation technique was used in which drug containing chitosan solution added into tripolyphosphate solution. Obtained beads were evaluated to study the effect of Span 80 and methods of drying on their properties. Air drying method resulted in shrunken beads, the oven drying method resulted in dark, brittle and cracked beads, and freeze-drying method showed adverse effect on sphericity and surface topography of the beads. Higher proportion of Span 80 in the beads showed faster release. Oven-dried beads gave delayed release compared to air- and freeze-dried beads. In vitro drug release data depicted t70%at 365 min with 88.17 % drug release for 12 h. Thus, formation of controlled release beads can be inferred.