Abstract Dendritic cells (DCs), as potent antigen presenting cells, are known to play a central role in the pathophysiology of asthma. The understanding of DC biology has evolved over the years to include multiple subsets of DCs with distinct functions in the initiation and maintenance of asthma. Furthermore, asthma is increasingly recognized as a heterogeneous disease with potentially diverse underlying mechanisms. The goal of this review is to summarize the role of DCs and the various subsets therein in the pathophysiology of asthma and highlight some of the crucial animal models shaping the field today. Potential future avenues of investigation to address existing gaps in knowledge are discussed.
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机译：摘要 树突状细胞（DCs）作为强效抗原呈递细胞，在哮喘的病理生理学中起着核心作用。多年来，对 DC 生物学的理解已经发展到包括多个 DC 亚群，这些 DC 在哮喘的发生和维持中具有不同的功能。此外，哮喘越来越被认为是一种具有潜在多种潜在机制的异质性疾病。本综述的目的是总结DCs及其各个亚群在哮喘病理生理学中的作用，并强调塑造当今该领域的一些关键动物模型。讨论了未来潜在的调查途径，以解决现有的知识差距。
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