Mechanism of Action of Lycoricidinol, a Plant Growth Inhibitor Isolated fromLycoris radiataHerb.

摘要

We studied the action mechanism of lycoricidinol, a plant growth inhibitor isolated fromLycoris radiataHerb. Lycoricidinol inhibited protein synthesis in mung bean hypocotyls, but not RNA synthesis. Protein synthesis inEscherichia coliwas not affected by the inhibitor. Results of in vitro translation experiments with the wheat germ system and theE. colisystem indicated that lycoricidinol inhibited only eukaryotic but not prokaryotic translation. Use of specific inhibitors of initiation and polypeptide chain elongation of polypeptide synthesis revealed that chain elongation was inhibited by lycoricidinol.