Synthesis of arsonium salts and betaines based on triphenylarsine and omega-bromoalkanoic acids

摘要

The reactions between Ph3As and omega-bromoalkanoic acids with the length of polymethylene fragment n = 5, 7, 9 afford quaternary arsonium salts. Their treatment with alkali gives biologically active arsenobetaines. Solvent-free reactions of Ph3P or Ph3As with 2,3-dibromopropionic acid lead to the corresponding arsonium and phosphonium salts bearing (CH2)(2)COOH substituent.