SCREENING THE ANTICANCEROUS EFFICACY OF TAMARINDUS INDICA L. USING MINERAL OIL INDUCED SWISS ALBINO MICE

摘要

In the present investigation reveals that anti-cancerous activity of Tamarindus indica L. leaves which serves as a simple and effective means of reducing the cancer. In Swiss albino mice the cancer state was induced by intraperitonial injection of mineral oil at a dose of 1 mL / kg of body weight for 21 days. The tail length of the normal mice was 9.6 cm whereas the mice with metastasize tumor in the head had a tail length of 5.8 cm, metastasize throat cancer mice had 5.9 cm of tail length and the mice with plasmacytoma alone had the tail length of 5.4 cm. The anticancerous activity of A. aspera leaves was tested against mineral oil induced cancer mice. Simultaneously a group of mice was first intraperitoneally injected with the sublethal doses (3 mg/ mL and 1.5 mg/ mL) of ether extract for 15 days. After 15 days the extract given mice were treated with 1 mL/kg of mineral oil periodically for 21 days. It was found that none of the mice got the symptoms of cancer. The present work clearly indicatesthat the ether extract at the concentration of 3 mg/ mL is very effective in reducing the cancer symptoms. The result of phytochemical analysis of leaf extracts showed that the extracts contains remarkable amount of phytochemicals which include alkaloid,tannin, saponin and aminoacids which adversely affect the growth of the tumours.