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Haptoglobin: the hemoglobin detoxifier in plasma

机译:Haptoglobin: the hemoglobin detoxifier in plasma

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摘要

Hemoglobin (Hb) is one of the most studied proteins. However, oxidative toxicity associated with free Hb in circulation and its contribution to inflammation and complications of transfusion have only recently become active areas of research. New insights into the protective mechanisms of haptoglobin (Hp), a plasma protein, and a timely resolution of the crystal structure of the Hb-Hp complex made it possible to definitively link the functional and structural interplay between the two proteins. Here, we summarize current knowledge of the interactions between Hb and Hp under oxidative stress conditions, and how Hb's own damaging radicals are harnessed by complex formation. Potential therapeutic benefits of using Hp for inactivation and clearance of free Hb under a number of clinical settings are considered.

著录项

  • 来源
    《Trends in biotechnology》 |2013年第1期|2-3|共2页
  • 作者单位

    Laboratory of Biochemistry and Vascular Biology, Center for Biologies Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA;

    Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark;

    Department of Pure and Applied Biochemistry, Lund University, Lund, Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 英语
  • 中图分类 普通生物学;
  • 关键词

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