This descriptive case study aimed at assessing body's composition and impact on biochemical markers of people living with HIV/AIDS (S1=male-1, S2=female-1) undergoing a four-month intervention program of resistance exercises. Was analyzed the lipid profile (total cholesterol, LDL, HDL and triglycerides serum), immunological parameters (CD4 and viral load/VL) and morphological parameters (body mass index BMI, waist/Hip/WHR, perimeters and skinfold). Blood samples and antropometric measures were obtained in the pre-exercise (pre-test) and immediately after (16 weeks) of exercise (post-test). An increase in HDL (38 pre, 42 post), LDL (89.6 pre, 95 post) was noted for S1 and a decrease in HDL (33 pre, 25 post) and LDL (121.6 pre, 121 post) for S2; a decrease in Triglyceride for S1 (292 pre, 214 post) and increase for S2 (102 pre, 166 post). Total cholesterol increased for both subjects (186 pre, 261 post S1 and 175 pre, 179 post S2). there was a decrease in CD4 for S1 (598 pre, 577 post) and an increase for S2 (748 pre, 1.071 post). With respect to viral load, we found that both subjects (S1 and S2) presented values below the minimum limit (pre and post test), with no significant changes. Body composition improved (LMpre S1=43.13% and S2=23.35% and LMpost S1=46.51 and S2=26.15%; BFpre S1=41.13 and S2=18.14% and BFpost S1=38.32 and S2=14.77%), as did BMI (25.27 pre, 27.44 post S1) and (24.24 pre, 24.74 post S2). The resistance exercise program as base in this intervention model promoted a healthy state for HIV and AIDS patients and did not pose any health risks to them.
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