Dear Sir:We read with great interest the insightful article published by Eelderink et al (1). Their highly relevant findings encourage further analysis and add complexity to the assessment and interpretation of the role of glycemic index in energy homeostasis. Such novel results contribute to explain why a beneficial effect of glycemic index on human metabolism has been difficult to prove under the conventional way of classifying carbohydrates, ie, by determining blood glucose concentration (2, 3). We here highlight some aspects that may deserve discussion.
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