Carbonylation of Anthranilic Acid with Aryl and Heteroaryl Bromides to Synthesize Benzoxazinone Derivatives

摘要

A simple and efficient, PdCl2(PhCN)(2)/P(tBu)(3)center dot HBF4-catalyzed carbonylative cyclization of anthranilic acid with aryl bromide was investigated for the synthesis of benzoxazinones under mild reaction conditions. The developed protocol has been extended for the synthesis of quinazolin-4(3H)-ones. Furthermore, the tolerance of a wide range of functional groups on anthranilic acid as well as on aryl bromide demonstrates the practical utility of the protocol.