Palladium-Catalyzed Cascade Reactions of -Halo-N-Tosylhydrazones, Indoles, and Aryl Iodides

摘要

-Halo-N-tosylhydrazones are explored as reagents for the multiple carbon-carbon bond formations in palladium-catalyzed three-component reactions. A strategy has been designed for this transformation by using a nucleophile to react with the azoalkene intermediate formed in situ from the -halo-N-tosylhydrazone to generate the diazo intermediate, which is further subjected to palladium-catalyzed C-C bond forming reactions with aryl iodides.