Suspect and non-target screening based on the use of high-resolution mass spectrometry (HRMS) has become more common in water analysis over the past years. However, this only yields lists of features or suspects without quantitative information. To expand the use of HRMS data to a quantitative screening, we have developed and validated a simple and fast method for more than 140 micropollutants using ultra high-performance liquid chromatography coupled to traveling wave ion mobility quadrupole time-of-flight mass spectrometry (UPLC-IM-Q-TOF-MS). Positive findings from suspect and non-target screening can be prioritized and identified by reference standards. The quantitative screening is then performed by additional measurement of calibration standards. This is carried out by means of direct injection and external calibration, without consideration of matrix effects. For all substances, limits of quantification (LOQs) of less or equal than 100 ng/L are achieved. The calibration is carried out in a range of 100 to 1000 ng/L and the results are reported as concentration ranges, in which the concentration of the analyte in the sample is to be expected. All substances were evaluated using quadratic regressions. For the verification of the accuracy, different water matrices (drinking water, groundwater, and surface water) were spiked with five concentration levels (50 ng/L, 300 ng/L, 500 ng/L, 800 ng/L, and 2000 ng/L) and indicate that for the drinking water and groundwater sample, 97% correct assignments were found, whereas for the surface water sample, 88% correct assignments were achieved. A comparative study of water samples of various matrices was accomplished using the quantitative screening analysis method and validated target methods by means of three UPLC tandem mass spectrometry (MS/MS) methods and two gas chromatography (GC) coupled to MS and MS/MS methods. A total of 510 data could be compared, which showed a good match of both approaches in more than 80% of th
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