Mechanisms of energy dissipation and relationship with tissue composition in human meniscus

摘要

Objective: The human meniscus is essential in maintaining proper knee joint function. The meniscus absorbs shock, distributes loads, and stabilizes the knee joint to prevent the onset of osteoarthritis. The extent of its shock-absorbing role can be estimated by measuring the energy dissipated by the meniscus during cyclic mechanical loading. Methods: Samples were prepared from the central and horn regions of medial and lateral human menisci from 8 donors (both knees for total of 16 samples). Cyclic compression tests at several compression strains and frequencies yielded the energy dissipated per tissue volume. A GEE regression model was used to investigate the effects of compression, meniscal side and region, and water content on energy dissipation in order to account for repeated measures within samples. Results: Energy dissipation by the meniscus increased with compressive strain from similar to 0.1 kJ/m(3) (at 10% strain) to similar to 10 kJ/m(3) (at 20% strain) and decreased with loading frequency. Samples from the anterior region provided the largest energy dissipation when compared to central and posterior samples (P < 0.05). Water content for the 16 meniscal tissues was 77.9 (C.I. 72.0-83.8%) of the total tissue mass. A negative correlation was found between energy dissipation and water content (P < 0.05). Conclusion: The extent of energy dissipated by the meniscus is inversely related to loading frequency and meniscal water content. (C) 2022 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.