A Janus Au–Polymersome Heterostructure with Near-Field Enhancement Effect for Implant-Associated Infection Phototherapy

摘要

Polymer–inorganic hybrid Janus nanoparticles (PI-JNPs) have attractedextensive attention due to their special structures and functions. However,achieving the synergistic enhancement of photochemical activity betweenpolymer and inorganic moieties in PI-JNPs remains challenging. Herein, theconstruction of a novel Janus Au–porphyrin polymersome (J-AuPPS) heterostructureby a facile one-step photocatalytic synthesis is reported. The nearfieldenhancement (NFE) effect between porphyrin polymersome (PPS) andAu nanoparticles in J-AuPPS is achieved to enhance its near-infrared (NIR)light absorption and electric/thermal field intensity at their interface, whichimproves the energy transfer and energetic charge-carrier generation. Therefore,J-AuPPS shows a higher NIR-activated photothermal conversion efficiency(48.4%) and generates more singlet oxygen compared with non-Januscore–particle Au–PPS nanostructure (28.4%). As a result, J-AuPPS exhibitsexcellent dual-mode (photothermal/photodynamic) antibacterial and antibiofilmperformance, thereby significantly enhancing the in vivo therapeuticeffect in an implant-associated-infection rat model. This work is believed tomotivate the rational design of advanced hybrid JNPs with desirable NFEeffect and further extend their biological applications.