Regioselective Synthesis of 5H-Benzo4,5imidazo2,1-aisoindole Linked 1,2,3-Traizole Hybrids and Their Anti-Proliferative Activity

摘要

Copper(I) catalyzed regioselective synthesis of some novel 5H-benzo[4,5]imidazo[2,1-a]isoindole linked 1,2,3-traizole hybrids has been developed. Structures of the synthesized compounds have been confirmed by IR, H-1, and C-13 NMR, and mass spectra. The in vitro tests against four human cancer cell lines, MCF-7, HeLa, A549, and IMR32, have exhibited notable anticancer activity of some products comparable with that of the standard drug etoposide. Molecular docking studies carried out with epidermal growth factor receptor (PDB ID- 4HJO) have supported anticancer activity of the compounds.