Selected lines of Aedes aegypti with persistently distorted sex ratios.

摘要

A breeding scheme to isolate X chromosomes sensitive to drive by the T8 (Trinidad) Y chromosome of A. aegypti (the MD haplotype) is reported. Crosses with an Australian strain Th.I (Thursday Island) revealed not only sensitive and resistant X chromosomes, but also some with the capacity to drive against the T8 Y chromosome. 4 strains were created in which sex ratio was male-distorted (28-36% female) for 10 generations, with no regression towards sexual parity. The proportion of females varied significantly between generations in each of the 4 strains. Further selection produced strains with normal sex ratios, capable of generating fewer than 15% female on outcrossing to T8 males.