SOLID-PHASE SYNTHESIS OF DIFLUOROBENZEVHDAZOLES AND DIFLUORO-2-QUINOXALINOLS

摘要

Over the history of drag discovery,heterocyclic structures often show interesting features and display favorable biological activity.Most approved therapeutic agents as well as drug candidates are derived from heterocyclic compounds.As solid-phase organic synthesis holds some important advantages over solution-phase procedure,not surprisingly more than 80 of combinatorial syntheses are performed on solid support.In particular,because of the tremendous functional diversity and drug-like potentials,current interest in solid-phase chemistry is focussed on small heterocycles.