SummaryTwo autopsy cases of moter neuron disease, progressive spinal muscular atrophy and amyotrophic lateral sclerosis, were presented. In both cases, the process was essentially degenerative with selective or predominant involvement of motor neuron system. Topographical studies, however, revealed unusual concomitants, involvement of the upper neuron in the former case and of extra pyramidal motor nuclei in the latter. No factors of etiological significance was demonstrated.
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