Proinflammatory Event of Ozonized Olive Oil in Mice

摘要

abstract_textpOzonized olive oil inhibited the swelling reaction of 2, 4-dinitrofluorobenzene-induced mouse-contact hypersensitivity, which is a model for chronic skin diseased involved in the initiation and propagation of several inflammatory processes, mainly due to type IV hypersensitivity. On the other hand, ozonized olive oil itself stimulated the development of inflammatory responses, such as vasodilation, swelling and epidermal hyperplasia. When repeatedly applied to the skin, ozonized olive oil caused hair loss at the site and contact hypersensitivity. These findings identify a new biological function for ozonized olive oil and indicate the risk of adverse effects with repeated application./p/abstract_text