ABSTRACTThe effect of subconjunctival retention of perfluoropropane (C3F8) gas on rabbit trabeculectomy was evaluated in this study to determine if this maneuver would increase the success rate of the surgery. Sixteen New Zealand white rabbits underwent trabeculectomy in the right eyes and trabeculectomy with subconjunctival retention of 0.3 mL C3F8gas in the left eyes were used as animal models. One week and six weeks after the operations, the intraocular pressure (IOP) dynamics were compared between the two eyes after intravenous infusion of 0.9% NaCl sterile solution. The results showed that the average retention time of C3F8gas within the subconjunctival space in the rabbits was 9.5 ± 2.3 days. There were four parameters available in comparing IOP dynamics: Time Needed to Reach Peak IOP (TNRPI); Ascending Slope(AS); Peak IOP (PI) and Time Needed to Return to the Original IOP (TNROI). It was noted that at the 7thday after the operations, the IOPs in both eyes of the rabbits were not significantly increased after intravenous infusion of 0.9% NaCl solution. At the 42ndday, after 0.9% NaCl intravenous infusion, the eyes that had undergone trabeculectomy and subconjunctival retention of C3F8gas had less IOP spiking than eyes that had undergone trabeculectomy alone (TNRPI: 6.7±2.2 vs. 4.2+2.9, p=0.01, AS: 0.5±0.3 vs. 2.8±2.7, p=0.002, PI: 24.4±9.6 vs.18.7±7.4, p=0.07 and TNROI: 6.8±5.8 vs. 14.7±11, p=0.02). Our study suggested that subconjunctival retention of C3F8gas increased the success rate of trabeculectomy in rabbits in the short-term follow-up
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