In vitro studies on H‐2‐linked unresponsiveness to synthetic polypeptides

摘要

AbstractThein vitroproduction, assay and partial characterization of an extremely potent antigen‐specific T helper cell factor to poly‐L‐(Tyr, Glu)‐poly‐DL‐Ala‐poly‐L‐Lys [(T, G)‐A–L] which may be an important physiological mediator of T cell functionin vivois described. The factor has an antigen‐binding site, Ia and Ig‐like determinants on the same molecular complex. The response to (T, G)‐A‐L is under H‐2‐linked Ir gene control, some but not all low responder h