Isolated from the South African tree Combretum caffrum,combretastatin A-4 1(CA-4)is one of the most promising experimental anticancer drugs,targeting tumor vasculature.The combretastatin A-4 disodium phosphate prodrug 3(CA-4P)has emerged as the most useful form of this compound in preclinical in vivo models,as well as in clinical trials,due to the limited solubility of the parent molecule in water.
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