Selection of a Tetanus Toxoid for Hyperimmunization of Human Volunteers

摘要

Abstract.Five tetanus toxoids of different manufacture and of different concentrations were used to determine the most effective formulation and strength of toxoid for the production in human volunteers of sustained high levels of tetanus antitoxin suitable for the production of human tetanus immune globulin. The most satisfactory results were obtained with a fluid, low‐protein, column‐purified tetanus toxoid. 79% of volunteers injected with a 36 Lf dose of this material achieved antitoxin levels of ≥10 antitoxin units/ml. The mean duration of these levels was 125