Fasting total homocysteine (tHcy) concentration and mortality in older Mexican Americans.

摘要

OBJECTIVES: This study examines the association between tHcy on cardiovascular and noncardiovascular mortality. DESIGN: Longitudinal study of 1,633 Mexican Americans age>60 years recruited in 1998. Setting: Sacramento, California. MEASUREMENTS: Cox proportional models were used to estimate the effects of tHcy on mortality rate in the total sample and in a subgroup of subjects without a history of cardiovascular disease at baseline. RESULTS: About half of the cohort was born in Mexico. Among Mexican-born participants, high tHcy (>11.0 micromol/L) was associated with a higher rate of cardiovascular mortality compared to those with low tHcy concentration