Semiconducting Polymer Nanoparticles in the Second Near-Infrared Region for Biomedical Imaging and Therapy

摘要

Semiconducting polymers are attractive optical materials in optoelectronicdevices and biomedical applications because of their superior optical propertiesand remarkable versatility. Optical imaging in the second near-infraredwindow (NIR-Ⅱ) has become increasingly popular owing to the merits of largepenetration depth and high signal to noise ratio, leading to a great deal ofinterest in the exploration and development of optical probes in the NIR-Ⅱregion. In this review, recent advances in the development of semiconductingpolymer nanoparticles (SPNs) in the NIR-Ⅱ region for biomedical imagingand therapeutics are summarized. This review focuses on the design strategiesin semiconducting polymers toward enhancing their NIR-Ⅱ emission fordeep tissue imaging, improving their performance in photoacoustic imaging,utilizing their large absorptivity for photothermal and photodynamic therapy,and a number of comprehensive applications for multifunctional imagingand optical therapeutics. Finally, the current challenges of semiconductingpolymer probes are discussed and the perspectives on the future developmentin the field are shared.