Development of Dissolution Medium for Rofecoxib in Pharmaceutical Formulations

摘要

Rofecoxib is a non-steroidal antiinflammatory drug and selective cox-2 inhibitor,used in the treatment of rheumatoid arthritis especially in gastritis and ulcerative conditions.It is chemically designated as 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2-(5H)-furanone.In this present study,dissolution of rofecoxib from two commercial formulations was studied in two different media to evaluate their discriminating power.