Microwave Studies on Synthesis of Some New Heterocyclic Chalcone and Pyrimidine-2-thione Derivatives and Their Antibacterial Activity

摘要

Chalcone derivatives [l(a-j)] were prepared by condensing acetophenone with various substituted aldehydes.These chaicones react with hydrazme hydrate and glacial acetic acid to give 1-acetyl pyrazolines and in turn 1-acetyl pyrazolines react with various substituted aldehydes to give various chalcone derivatives.Pyrimidine-2-thione derivatives [2(a-j)] were prepared by condensing substituted chaicones with thiourea in presence of dil.HC1 by using ethanol as a solvent.All these reactions are carried out in borosil beaker under microwave irradiation in microwave oven.These products have been characterised by means of elemental analysis and IR spectral studies and tested for antibacterial activities against S.aureus and E.coii.