Estimation of Atorvastatin by High Performance Liquid Chromatography in Pure and Pharmaceutical Dosage Forms

摘要

A reverse phase high performance liquid chromatographic method has been developed for the estimation of atorvastatin in pure form and in pharmaceutical formulations.The quantification was carried out using a RPC-18 column in isocratic mode,with mobile phase consisting of acetonitrile,water and triethyl amine in the ratio of 800 : 200 : 0.2 (v/v).Beclomethasone dipropionate was used as an internal standard.The detection was carried out at 248 nm and the linearity was found to be in the range of 3-15 mug/mL.The proposed method was found to be simple,precise,accurate,less time consuming and reproducible for the estimation of atorvastatin in pharmaceutical dosage forms,i.e.,tablets.