Stereoselective Synthesis of Dialkyl 1,1-diacetyl-8a-hydroxy-8-oxo-1,2,8,8a-tetrahydrocyclopenta[a]indene-2,3-dicarboxylates from the Reaction of Dialkyl 2-(1-acetyl-2-oxopropyl)-3-(tributylphosphoranylidene)Succinates with Indene-1,2,3-trione

摘要

Protonation of the highly reactive 1:1 intermediates produced in the reaction between tributylphosphine and dialkyl acetylene-dicarboxylates by acetylacetone leads to sterically congested phosphorus ylides.Reaction between the sterically congested phosphorus ylides with ninhydrin leads to Stereoselective synthesis of dialkyl 1,1-diacetyl-8a-hydroxy-8-oxo-l,2,8,8a-tetrahydrocyclo-penta[a]indene-2,3-carboxylates in the presence of magnesium sui-fate powder in solvent-free conditions.