Interaction between Cu(II)and the Nucleobases in Solution

摘要

The interaction between Cu~(2+)and nucleobases viz.adenine and guanine,has been followed by UV-difference spectrophotometry,high pressure liquid chromatography and molecular modeling.Cu~(2+)is found to form 1:1,1:2 and 1:3 adducts with adenine and 2:1 and 1:1 adducts with guanine.In the adducts,the metal ion is believed in a distorted octahedral geometry being coordinated to adenine or guanine ligands and a number of water molecules.In all of the adducts except the 1:1 adduct between Cu~(2+)and guanine,there are one or more intramolecular H-bonds resulting into the formation of macrochelates.